Integrating analysis of proteome profile and drug screening identifies therapeutic potential of MET pathway for the treatment of malignant peripheral nerve sheath tumor.

Ryuto TsuchiyaYuki YoshimatsuRei NoguchiYooksil SinTakuya OnoTaro AkiyamaHidetaka KosakoAkihiko YoshidaSeiji OhtoriAkira KawaiTadashi Kondo

Published in: Expert review of proteomics (2023)

We successfully identified novel therapeutic candidates for the treatment of MPNST, namely crizotinib and foretinib, which target the MET pathway. We hope that these candidate drugs will contribute to the treatment of MPNST.

Keyphrases

peripheral nerve
genome wide
tyrosine kinase
dna methylation
combination therapy
drug induced
adverse drug