Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD8+ T cells in giant cell arteritis.

Rosanne D ReitsemaKornelis S M van der GeestMaria SandoviciWilliam F JiemyJacoba C GraverWayel H AbdulahadAnnemieke M H BootsPeter HeeringaElisabeth Brouwer

Published in: Rheumatology (Oxford, England) (2022)

In GCA, circulating effector memory CD8+ T cells demonstrate a proliferation-prone phenotype. The presence of CD8+ T cells in inflamed arteries seems to reflect recruitment of circulating cells rather than local expansion. CD8+ T cells in inflamed tissues produce IFN-γ, which is an important mediator of local inflammatory responses in GCA.

Keyphrases

giant cell
single cell
induced apoptosis
dendritic cells
signaling pathway
cell cycle arrest
rna seq
gene expression
immune response
working memory
regulatory t cells
genome wide
endoplasmic reticulum stress
cell death