Associations between schistosomiasis and HIV-1 acquisition risk in four prospective cohorts: a nested case-control analysis.
Aaron F BochnerJared M BaetenWilliam Evan SecorGovert J van DamAdam A SzpiroSammy M NjengaPaul L A M CorstjensAustin NewsamNelly R MugoConnie L CelumAndrew MujugiraR Scott McClellandRuanne V BarnabasPublished in: Journal of the International AIDS Society (2021)
Schistosomiasis was not a strong risk factor for HIV-1 acquisition in these four prospective studies. S. mansoni was responsible for the majority of schistosomiasis in these cohorts, and our results do not support the hypothesis that S. mansoni infection is associated with increased HIV-1 acquisition risk. S. haematobium infection was associated with a point estimate of elevated HIV-1 risk in the FSW cohort that was not statistically significant, and there was no trend towards a positive association in the serodiscordant couples cohorts.