HIV-1 Tat induced microglial EVs leads to neuronal synaptodendritic injury: microglia-neuron cross-talk in NeuroHIV.
Muthukumar KannanSeema SinghDivya T ChemparathyAbiola A OladapoDinesh Y GawandeShashank M DravidShilpa BuchSusmita SilPublished in: Extracellular vesicles and circulating nucleic acids (2022)
In summary, our study underscores the role of microglial NLRP3 as an important contributor to Tat-MDEV mediated synaptodendritic injury. While the role of NLRP3 in inflammation is well-described, its role in EV-mediated neuronal damage is an interesting finding, implicating it as a target for therapeutics in HAND.
Keyphrases
- inflammatory response
- neuropathic pain
- oxidative stress
- lipopolysaccharide induced
- lps induced
- antiretroviral therapy
- diabetic rats
- hiv positive
- hiv infected
- human immunodeficiency virus
- hepatitis c virus
- high glucose
- cerebral ischemia
- hiv testing
- small molecule
- spinal cord injury
- drug induced
- endothelial cells
- men who have sex with men