Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3.

Namgue HongHee Jung KimKeunsoo KangJi On ParkSeyoung MunHyung-Gun KimBong Hui KangPhil-Sang ChungMin Young LeeJin-Chul Ahn

Published in: Cell & bioscience (2023)

Our findings demonstrate that PBM attenuates epileptic excitotoxicity, neurodegeneration and cognitive decline induced by TLE through inhibition of the Nlgn3 gene decrease induced by excitotoxicity.

Keyphrases

cognitive decline
mild cognitive impairment
signaling pathway
cell proliferation
genome wide
copy number
mouse model
gene expression
transcription factor
genome wide analysis