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Serial integration of Dean-structured sample cores with linear inertial focussing for enhanced particle and cell sorting.

Paul M HollowayJonathan ButementManjunath HegdeJonathan J West
Published in: Biomicrofluidics (2018)
In this contribution, a channel aspect ratio of >2 was used to access high velocity regimes to provide confined sample cores by Dean focussing in advance of linear inertial focussing. This produces a singular separation origin with a mirrored transport path for efficient particle and blood cell sorting, while also increasing the spatial resolution for multiscale sorting.
Keyphrases
  • single cell
  • cell therapy
  • mesenchymal stem cells
  • liquid chromatography
  • blood flow