DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses.

Xueyi ShenDoretta CaramaschiMark J AdamsRosie M WalkerJosine L MinAlex KwongGibran Hemaninull nullMiruna C BarbuHeather C WhalleySarah E HarrisIan J DearyStewart W MorrisSimon R CoxCaroline L ReltonRiccardo E MarioniKathryn L EvansAndrew M McIntosh

Published in: Genome medicine (2022)

PRS for depression, especially those constructed from genome-wide significant genetic risk variants, showed methylome-wide differences associated with immune responses. Findings from MR analysis provided evidence for causal effect of DNAm to depression.

Keyphrases

genome wide
immune response
depressive symptoms
copy number
sleep quality
dna methylation
toll like receptor
magnetic resonance
cell free
single molecule
circulating tumor
data analysis