In past decades, nanoscale metal-organic frameworks (NMOFs) have drawn more and more attention in multimodal imaging and targeting therapy of various malignant cancers. Here, we proposed to dope 111 In into fluorescent In-based NMOFs (In-MIL-68-NH 2 ), with an attempt to prepare a new nanomedicine with great anticancer potential. As a proof of concept, the obtained NMOF (In-MIL-68/PEG-FA) with targeting motifs is able to act as a fluorescent probe to achieve Hela cell imaging. Moreover, the Auger electron emitter 111 In built in corresponding radioactive NMOF ( 111 In-MIL-68/PEG-FA) can bring clear damage to cancer cells, leading to a high cell killing rate of 59.3 % within 48 h. In addition, the cell cycle presented a significant dose-dependent G2/M inhibiting mode, which indicates that 111 In-MIL-68/PEG-FA has the ability to facilitate the cancer cells to enter apoptotic program. This work demonstrated the potential of 111 In-labelled NMOFs in specific killings of cancer cells, providing a new approach to develop nanomedicines with theranostic function.
Keyphrases
- metal organic framework
- living cells
- cell cycle
- fluorescent probe
- drug delivery
- cell cycle arrest
- cancer therapy
- cell death
- high resolution
- single cell
- solid phase extraction
- induced apoptosis
- cell therapy
- quantum dots
- cell proliferation
- fluorescence imaging
- signaling pathway
- oxidative stress
- working memory
- photodynamic therapy
- pain management
- single molecule
- risk assessment
- pi k akt
- endoplasmic reticulum stress
- climate change
- mass spectrometry
- ionic liquid
- tandem mass spectrometry