Transcranial Blood-Brain Barrier Opening in Alzheimer's Disease Patients Using a Portable Focused Ultrasound System with Real-Time 2-D Cavitation Mapping.

Sua Bae Keyu Liu Antonios N Pouliopoulos Robin Ji Sergio Jiménez-Gambín Omid Yousefian Alina R Kline-Schoder Alec J BattsFotios N TsitsosDanae Kokossis Akiva Mintz Lawrence S Honig Elisa E Konofagou

Published in: medRxiv : the preprint server for health sciences (2024)

We showed the safety and feasibility of this cost-effective and time-efficient portable NgFUS treatment for BBBO in AD patients with the first demonstration of real-time 2-D cavitation mapping. The cavitation dose correlated with BBBO volume, a slowed increase in pathology, and serum detection of AD proteins. Our study highlights the potential for accessible FUS treatment in AD, with or without drug delivery.

Keyphrases

blood brain barrier
drug delivery
end stage renal disease
high resolution
chronic kidney disease
ejection fraction
newly diagnosed
peritoneal dialysis
cerebral ischemia
high density
brain injury
replacement therapy
sensitive detection
mild cognitive impairment