Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma.

Caitlin A McIntyreSharon A LawrenceAllison L RichardsJoanne F ChouWinston WongMarinela CapanuMichael F BergerMark T A DonoghueKenneth H YuAnna M VargheseDavid P KelsenWungki ParkVinod P BalachandranT Peter KinghamMichael I D'AngelicaJeffrey A DrebinWilliam R JarnaginChristine A Iacobuzio-DonahuePeter J AllenEileen M O'Reilly

Published in: Cancer (2020)

In patients with resected PDAC, genomic alterations in KRAS and TP53 are associated with worse outcomes, whereas alterations in HRD genes are associated with a favorable prognosis. Further studies are needed to better define these alterations as biomarkers in resected PDAC.

Keyphrases

lymph node
genome wide
prognostic factors
type diabetes
gene expression
bioinformatics analysis
adipose tissue
metabolic syndrome
copy number
transcription factor