New pro-inflammatory cytokine IL-40 is produced by activated neutrophils and plays a role in the early stages of seropositive rheumatoid arthritis.

Adéla NavrátilováViktor BečvářHana HulejováMichal TomcikLucie ŠtolováHeřman MannOlga RůžičkováOlga ŠléglováJakub ZávadaKarel PavelkaJiří VencovskýLadislav ŠenoltLucie Andrés Cerezo

Published in: RMD open (2023)

We showed that IL-40 is significantly up-regulated in seropositive ERA and decreases after conventional therapy. Moreover, neutrophils are an important source of IL-40 in RA, and its release is potentiated by cytokines and NETosis. Thus, IL-40 may play a role in ERA.

Keyphrases

rheumatoid arthritis
disease activity
mesenchymal stem cells
stem cells
transcription factor
systemic lupus erythematosus
idiopathic pulmonary fibrosis