Nationwide study of pediatric B-cell precursor acute lymphoblastic leukemia with chromosome 8q24/MYC rearrangement in Japan.
Kimiyoshi SakaguchiToshihiko ImamuraSae IshimaruChihaya ImaiHidemi ShimonodanNaoto FujitaKeiko OkadaTakeshi TaketaniRie KanaiHisamichi TauchiMotohiro KatoYasuko KojimaArata WatanabeTakao DeguchiYoshiko HashiiNobutaka KiyokawaTomohiko TakiAkiko M SaitoKeizo HoribeAtsushi ManabeAtsushi SatoKatsuyoshi KohPublished in: Pediatric blood & cancer (2020)
The clinical and laboratory features of BL with IG-MYC rearrangement, displaying a BCP immunophenotype (Wagener et al. and Herbrueggen et al. termed it as pre-BLL), are similar to those of BCP-ALL with 8q24/MYC-r. Low-risk ALL-type chemotherapy may not be appropriate for them, and further studies are required to establish an adequate therapeutic strategy. Further studies of DHL to identify new treatment strategies are also needed.