ClonoScreen3D - A Novel 3-Dimensional Clonogenic Screening Platform for Identification of Radiosensitizers for Glioblastoma.

Mark R JacksonAmanda R RichardsAbdul-Basit Ayoola OladipupoSandeep K ChahalSeamus CaragherAnthony J ChalmersNatividad Gomez-Roman

Published in: International journal of radiation oncology, biology, physics (2024)

The ClonoScreen3D platform was demonstrated to be a robust method to screen for single agent and radiation-drug combination activity. Using gold-standard clonogenicity, this assay is a tool for identification of radiosensitizers. We anticipate this technology will accelerate identification of novel radiation-drug combinations with genuine translational value.

Keyphrases

high throughput
bioinformatics analysis
emergency department
radiation induced
radiation therapy