Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter.

Joshua J WoodsMadison X RodriguezChen-Wei TsaiMing-Feng Tsai Justin J Wilson

Published in: Chemical communications (Cambridge, England) (2021)

We report our investigation into the MCU-inhibitory activity of Co3+ complexes in comparison to Ru265. These compounds reversibly inhibit the MCU with nanomolar potency. Mutagenesis studies and molecular docking simulations suggest that the complexes operate through interactions with the DIME motif of the MCU pore.

Keyphrases

molecular docking
molecular dynamics simulations
crispr cas
oxidative stress
molecular dynamics
reduced graphene oxide
gold nanoparticles
monte carlo