PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice.
Miljenko Valentin PanajatovicFrançois SinghNoëmi Johanna RoosUrs DuthalerChristoph HandschinStephan KrähenbühlJamal BouitbirPublished in: Acta physiologica (Oxford, England) (2019)
Simvastatin impairs skeletal muscle function, muscle oxidative metabolism and mitochondrial morphology preferentially in WT and KO mice, whereas OE mice appear to be protected, suggesting a role of PGC-1α in preventing simvastatin-associated myotoxicity.