DNA methylation near the INS gene is associated with INS genetic variation (rs689) and type 1 diabetes in the Diabetes Autoimmunity Study in the Young.

Patrick M CarryLauren A VanderlindenRandi K JohnsonFran DongAndrea K SteckBrigitte I FrohnertMarian RewersIvana V YangKaterina KechrisJill M Norris

Published in: Pediatric diabetes (2020)

We confirmed an association between DNA methylation and rs689 that has been identified in related studies. Measurements in our study preceded the onset of T1D suggesting methylation may have a role in the relationship between INS variation and T1D development.

Keyphrases

dna methylation
type diabetes
genome wide
gene expression
cardiovascular disease
copy number
metabolic syndrome
transcription factor
middle aged
weight loss