Differences in responses to the intracellular macrophage environment between Mycobacterium bovis BCG vaccine strains Moreau and Pasteur.
Paloma Rezende CorrêaMarcos Gustavo Araujo SchwarzRenata Monteiro MaiaFátima Maria Figueroa VergaraMilton Ozório MoraesLeila Mendonça-LimaPublished in: Memorias do Instituto Oswaldo Cruz (2023)
Overall, our results show that, compared to Pasteur, BCG Moreau has increased fitness and better endurance in the harsh intracellular environment, also regulating anti-microbial responses (lower IL-1b and MCP-1). These findings contribute to the understanding of the physiology of BCG Moreau and Pasteur in response to the intraphagosomal environment in a THP-1 macrophage model.