Association of metformin use on metabolic acidosis in diabetic patients with chronic hepatitis B-related cirrhosis and renal impairment.
Terry Cheuk Fung YipRaymond Ngai Chiu ChanVincent Wai-Sun WongYee-Kit TseLilian Yan LiangVicki Wing-Ki HuiXinrong ZhangGuan-Lin LiHenry Lik-Yuen ChanGrace Lai-Hung WongPublished in: Health science reports (2021)
In conclusion, patients with Child-Pugh class B cirrhosis or above were at a higher risk of metabolic acidosis. Metformin further increased the risk in patients with Child-Pugh class B cirrhosis or above and stage 3A CKD or above. Dose adjustment in stage 4/5 CKD did not reduce the risk of metabolic acidosis.