11 C-PK11195 PET-based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis.
Giacomo TondoLeonardo IaccarinoChiara CeramiGiovanna Emilia VanoliLuca PresottoValeria MasielloAngela ColivaFabrizio SalviIlaria BartolomeiLorena MoscaChristian LunettaDaniela PeraniPublished in: Annals of clinical and translational neurology (2020)
In vivo neuroinflammation occurred in all SOD1 mutated cases since the presymptomatic stages, as shown by a significant cortical and subcortical microglia activation. The involvement of sensorimotor cortex became evident at the symptomatic disease stage. Although our data indicate the role of in vivo PET imaging for assessing resident microglia in the investigation of SOD1-ALS pathophysiology, further studies are needed to clarify the temporal and spatial dynamics of microglia activation and its relationship with neurodegeneration.
Keyphrases
- amyotrophic lateral sclerosis
- pet imaging
- inflammatory response
- neuropathic pain
- lipopolysaccharide induced
- functional connectivity
- positron emission tomography
- computed tomography
- traumatic brain injury
- patient safety
- electronic health record
- pet ct
- quality improvement
- multiple sclerosis
- brain injury
- case control
- single molecule