Expedient delivery of quinolinone drugs via a traceless N -nitroso enabled oxidative Heck/amidation cascade.

Zhongyuan LiXiaojian ChenHulin ZhongYitong LinYang Gao Yuan Liu Qian Chen Yan-Ping Huo Xianwei Li

Published in: Chemical communications (Cambridge, England) (2022)

The exploration of green C-H oxidation for the rapid construction of functional molecules, remains a permanent goal in synthetic chemistry. Herein, a traceless N -nitroso enabled oxidative Heck and amidation cascade was realized, leading to quinolinones that feature green oxidation and great functional group tolerance. The expedient construction of quinolinone containing pharmaceuticals including Flucarbril, Clostamide and Aripiprazole was achieved in a concise and environmentally friendly manner.

Keyphrases

hydrogen peroxide
deep learning
low cost
neural network
sensitive detection