Ischemic-Preconditioning Induced Serum Exosomal miR-133a-3p Improved Post-Myocardial Infarction Repair via Targeting LTBP1 and PPP2CA.
Na YangYong-Bo HouTian-Hao CuiJun-Ma YuShu-Fang HeHai-Juan ZhuPublished in: International journal of nanomedicine (2024)
IPC-exo inhibit excessive replacement fibrosis and improve cardiac function post-MI by transferring miR-133a-3p, the mechanism is associated with directly targeting LTBP1 and PPP2CA, and indirectly regulating TGF-β pathway in rats. Our finding provides potential therapeutic effect of IPC-induced exosomal miR-133a-3p for cardiac repair.
Keyphrases
- high glucose
- diabetic rats
- left ventricular
- heart failure
- cancer therapy
- ischemia reperfusion injury
- drug induced
- endothelial cells
- oxidative stress
- transforming growth factor
- cerebral ischemia
- physical activity
- body mass index
- protein kinase
- epithelial mesenchymal transition
- weight gain
- atrial fibrillation
- brain injury