Stromal cells and B cells orchestrate ectopic lymphoid tissue formation in nasal polyps.

Zhe-Zheng WangJia SongHai WangJing-Xian LiQiao XiaoZe YuZhi-Chao WangJin-Xin LiuLi PanYin YaoCai-Ling ChenXiang LuChao-Hong Liu Pei-Song Gao Zheng Liu

Published in: Allergy (2020)

We identified an important role of IL-17A-induced stromal cell remodeling in the initiation and crosstalk between B and stromal cells via CXCL13 and LTα1 β2 in the enlargement of eLTs in NPs.

Keyphrases

chronic rhinosinusitis
high glucose
single cell
diabetic rats
bone marrow
cell therapy
drug induced
stem cells
oxidative stress
mesenchymal stem cells