Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence.

Miriam SeboldMaria GarbusowDeniz CerciKe ChenChristian SommerQuentin Jm HuysStephan NebeMichael RappIlya M VeerUlrich S ZimmermannMichael N SmolkaHenrik WalterAndreas HeinzEva Friedel

Published in: Journal of psychopharmacology (Oxford, England) (2021)

These results support a role for the opioid system in incentive salience motivation. Furthermore, they inform a mechanistic model of aberrant salience processing and are in line with the pharmacological potential of opioid receptor targets in the treatment of AD.

Keyphrases

chronic pain
pain management
functional connectivity
risk assessment
alcohol consumption
combination therapy