Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk.

N Mustonen Heli SiljanderA PeetV TillmannT HärkönenJ IlonenH HyötyOlli H Laitinennull null

Published in: Pediatric diabetes (2017)

Early childhood infections may play an important role in the pathogenesis of T1D. Current findings may reflect either differences in microbial exposures or early immunological aberrations making diabetes-prone children more susceptible to infections.

Keyphrases

type diabetes
young adults
cardiovascular disease
glycemic control
single cell
air pollution
microbial community
stem cells
cell therapy
gene expression
copy number
mesenchymal stem cells
metabolic syndrome
adipose tissue
celiac disease