Copper-Catalyzed Phosphonylation/Trifluoromethylation of N-p-NO2-Benzoylacrylamides Coupled with Dearomatization and Denitration.

A novel and efficient copper-tert-butyl hydroperoxide mediated intramolecular spirocyclization of N-p-NO2-benzoylacrylamides through a cascade radical addition-ipso-cyclization-dearomatization-denitration process has been developed, affording a convenient and powerful tool for the preparation of valuable phosphonated or trifluoromethylated azaspiro[4.5]decadientriones under mild conditions in good yields.