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Construction of the Bicyclic Carbon Framework of Euphosalicin.

David SchachamayrJohanna TemplMatthias WeilPeter GaertnerValentin S Enev
Published in: The Journal of organic chemistry (2024)
Our studies toward the total synthesis of the natural product euphosalicin ( 1 ) are presented. Different approaches targeting key intermediates are described, the synthesis of which includes findings on asymmetric dihydroxylations and ring-closing enyne metatheses (RCEYM). Their connection allowed the isolation of highly advanced precursors for studies on macrocyclizations. Our efforts culminated in the preparation of the unique C11/C12 ( Z ) isomer of the C13 nor methyl skeleton of euphosalicin ( 1 ).
Keyphrases
  • case control
  • cancer therapy
  • quality improvement
  • molecularly imprinted
  • drug delivery
  • mass spectrometry
  • high resolution
  • solid state
  • liquid chromatography