X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore.

Hyunjun YangD R Du BoisJ W ZillerJ S Nowick

Published in: Chemical communications (Cambridge, England) (2018)

The X-ray crystallographic structure of a truncated teixobactin analogue reveals hydrogen-bonding and hydrophobic interactions and a cavity that binds a chloride anion. Minimum inhibitory concentration (MIC) assays against Gram-positive bacteria correlate the observed structure with antibiotic activity.

Keyphrases

high resolution
ionic liquid
molecular dynamics
gram negative
high throughput
magnetic resonance imaging
multidrug resistant