Evaluation of a new composite score combining SPICE and Protrusion Angle scores to distinguish submucosal lesions from innocent bulges.

Introduction/Aims In capsule endoscopy (CE), small bowel subepithelial lesions (SBSL) are difficult to distinguishing from innocent mucosal protrusions. The SPICE score (smooth, protruding lesions index on CE) and a score that assesses the SBSL protrusion angle were developed. We intend to determine if a composite score is superior to the proposed models. Methods All CE between 01/2010 and 12/2020 were included if a smooth, round protruding lesion was identified. Both scores and a composite score (SPICE>2 and Angle<90º) were calculated after video review. Mucosal protrusions were defined as SBSL if they had a histological/imaging diagnosis and innocent protrusions if otherwise. All patients without at least one appointment and an additional diagnostic exam after CE were excluded. Results A total of 34 CE included, 64.7% men, age 65.4±14.7 years. The most common indication for CE was anemia (52.9%). SBSL were identified in 17 cases, with lipomas (14.7%) being the most frequent diagnosis. Both the SPICE (AUROC 0.90, p<0.001) and protrusion angle scores (AUROC 0.74, p=0.019) accurately distinguished SBSL from innocent protrusions. Applying a 90º cut-off, the protrusion angle has a sensitivity of 52.9% and specificity of 88.2%. Applying a cut-off of >2 points, the SPICE score has a sensitivity of 64.7% and specificity of 94.2%. The composite score had a sensitivity, specificity, positive and negative predictive value of 47.0%, 100%, 100% and 65.4%. Conclusion We propose that in cases where both a SPICE>2 and angle of <90º are obtained, additional follow-up investigation should always be undertaken, as the likelihood of SBSL is high.