Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer.

Henning Tim LangerShakti RamsamoojEzequiel DantasAnirudh MurthyMujmmail AhmedSeo-Kyoung HwangRahul GroverRita PozovskiyRoger J LiangAndre Lima QueirozJustin C BrownEileen P WhiteTobias JanowitzMarcus D Goncalves

Published in: bioRxiv : the preprint server for biology (2023)

- The PPAR-γ agonist, rosiglitazone, restores circulating adiponectin levels in mice with lung cancer.- Rosiglitazone preserves skeletal muscle and adipose tissue mass in mice with lung cancer.- The preservation of muscle mass with rosiglitazone is associated with increases in AMPK and AKT activity.- Stimulation of adiponectin signaling increases AMPK activity, anabolic signaling, and protein synthesis in muscle cell culture.

Keyphrases

insulin resistance
skeletal muscle
high fat diet induced
adipose tissue
metabolic syndrome
high fat diet
cell proliferation
signaling pathway
mouse model