Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation.

Nahyeon KangSu Yeon ChoiBit Na KimChang Dong YeoChan Kwon ParkYoung Kyoon KimTae-Jung KimSeong-Beom LeeSug Hyung LeeJong Y ParkMi Sun ParkHyeon Woo YimSeung Joon Kim

Published in: BMC cancer (2019)

These results suggest that hypoxia-induced acquisition of cancer stem cell characteristics was associated with CXCR4 activation by its aberrant promoter demethylation.

Keyphrases

cancer stem cells
dna methylation
transcription factor
gene expression
papillary thyroid
stem cells
cell migration
epithelial mesenchymal transition
lymph node metastasis