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Elevated FBXL6 activates both wild-type KRAS and mutant KRAS G12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice.

Hao-Jun XiongHong-Qiang YuJie ZhangLei FangDi WuXiao-Tong LinChuan-Ming Xie
Published in: Military Medical Research (2023)
-induced tumorigenesis, providing a potential therapeutic strategy to treat this aggressive subtype of liver cancer.
Keyphrases
  • wild type
  • cell proliferation
  • high glucose
  • signaling pathway
  • diabetic rats
  • dna damage
  • cell death
  • metabolic syndrome
  • adipose tissue
  • insulin resistance