Multiple Targets, One Goal: Compounding life-extending effects through Polypharmacology.
Konstantin AvchaciovKhalyd J ClayK DenisovO BurmistrovaMichael PetrascheckPeter O FedichevPublished in: bioRxiv : the preprint server for biology (2024)
The most effective known geroprotectors act by polypharmacological mechanisms.Graph neural networks predicted polypharmacological geroprotectors with a hit rate of 70%.The predicted polypharmacological geroprotectors are exceptionally effective.The predicted polypharmacological mechanism was experimentally confirmed.Rationally designing polypharmacological compounds results in geroprotectors with exceptional efficacy.
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