Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells.

Won-Mook ChoiTom RyuJun-Hee LeeYoung-Ri ShimMyung-Ho KimHee-Hoon KimYe Eun KimKeungmo YangKyurae KimSung Eun ChoiWon KimSeok-Hwan KimHyuk Soo EunWon-Il Jeong

Published in: Hepatology (Baltimore, Md.) (2021)

mGluR5 plays important roles in attenuating liver fibrosis by augmenting NK cell cytotoxicity, which could be used as a potential therapeutic target for liver fibrosis.

Keyphrases

liver fibrosis
natural killer cells
nk cells
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
oxidative stress
cell proliferation
climate change