A non-coding RNASEH1 gene variant associates with type 1 diabetes and interacts with HLA tagSNPs in families from Colombia.

Natalia Gomez-LoperaJuan-Manuel AlfaroAlejandra-Marcela RodriguezAlex RamirezSuzanne M LealNicolas Pineda-Trujillo

Published in: Pediatric diabetes (2020)

Our results verify the association of rs7607888 in RNASEH1 gene with T1D. It is also shown in the interaction between RNASEH1 and HLA for conveying risk to T1D in Northwest Colombia. Work is underway aiming to identify the actual classic HLA alleles associated with the tagSNPs tested here.

Keyphrases

copy number
genome wide
genome wide identification
binding protein
gene expression
transcription factor