Early Postoperative Treatment versus Initial Observation in CNS WHO Grade 2 and 3 Oligodendroglioma: Clinical Outcomes and DNA Methylation Patterns.

Maximilian J Mair Annette Leibetseder Gerwin Heller Rainer Puhr Erwin Tomasich Sebastian Goldberger Teresa Hatziioannou Adelheid Wöhrer Georg Widhalm Karin Dieckmann Martin Aichholzer Serge Weis Tim J von Oertzen Julia Furtner Josef Pichler Matthias Preusser Anna Sophie Berghoff

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

In this retrospective study, early postoperative treatment was not associated with improved PFS/OS in oligodendroglioma. The potentially predictive value of whole-genome methylation profiling should be validated in prospective trials.

Keyphrases

dna methylation
patients undergoing
genome wide
single cell
combination therapy