Pharmacokinetics of small hyperbranched polyglycerols as an osmotic agent for peritoneal dialysis: Plasma exposure, organ distribution and excretion in rats.

Caigan DuRoxana JayoAsher A MendelsonIrina ChafeevaGerald da RozaRichard LigginsJayachandran N Kizhakkedathu

Published in: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis (2023)

Data suggest size-dependent peritoneal absorption of osmotic HPG that are not specifically absorbed by any of the organs tested. The clearance of small HPG mainly depends on kidney excretion, implying the risk of HPG accumulation in patients with end-stage kidney disease who receive maintenance dialysis with HPG.

Keyphrases

peritoneal dialysis
end stage renal disease
chronic kidney disease
big data
machine learning
artificial intelligence