Inflammasome assembly is required for intracellular formation of β2-microglobulin amyloid fibrils, leading to IL-1β secretion.
Naoe KanekoWakako MoriMie KurataToshihiro YamamotoTamotsu ZakoJunya MasumotoPublished in: International journal of immunopathology and pharmacology (2022)
Taken together, these data suggest that inflammasome assembly is required for the subsequent triggering of intracellular formation of B2M amyloid fibrils, which may contribute to osteoarticular deposition of B2M amyloid fibrils and inflammation in patients with DRA.