Identification of High-Risk Multiple Myeloma With a Plasma Cell Leukemia-Like Transcriptomic Profile.

Davine Hofste Op Bruinink Rowan Kuiper Mark van Duin Tom Cupedo Vincent H J van der Velden Remco M Hoogenboezem Bronno van der Holt H Berna Beverloo Erik T Valent Michael Vermeulen Francesca Gay Annemiek Broijl Herve Avet-Loiseau Nikhil C Munshi Pellegrino Musto Phillipe Moreau Sonja ZweegmanNiels W C J van de DonkPieter Sonneveld

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)

pPCL was identified on the basis of a specific tumor transcriptome, which was also present in patients with high-risk NDMM, despite not being clinically leukemic. Incorporating PCL-like status into current risk models in NDMM may improve prognostic accuracy.

Keyphrases

single cell
rna seq
multiple myeloma
acute myeloid leukemia
bone marrow
gene expression
cell therapy
genome wide
dna methylation