Characterization of a recombinant factor IX molecule fused to coagulation factor XIII-B subunit.
Stéphanie DésageAlexandre LeuciNathalie EnjolrasLori A HolleSneha SinghXavier DelavenneAlisa S WolbergArijit BiswasDargaud YesimPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2023)
We report here the key interactions that rFIX-LXa-FXIIIB may have in plasma are with fibrinogen and albumin which may mediate its prolonged half-life. In addition, using the saphenous vein bleeding model, we demonstrate that rFIX-FXIIIB elicits functional clot formation that is indistinguishable from that of rFIX-WT.