Prenatal levonorgestrel exposure induces autism-like behavior in offspring through ERβ suppression in the amygdala.

Yuanlin ZouQiaomei LuDan ZhengZhigang ChuZhaoyu LiuHaijia ChenQiongfang RuanXiaohu GeZiyun ZhangXiaoyan WangWenting LouYongjian HuangYifei WangXiaodong HuangZhengxiang LiuWeiguo XieYikai ZhouPaul Yao

Published in: Molecular autism (2017)

We conclude that prenatal levonorgestrel exposure induces autism-like behavior in offspring through ERβ suppression in the amygdala. To our knowledge, this is the first time the potential effect of oral contraceptives on the contribution of autism-like behavior in offspring has been discovered.

Keyphrases

autism spectrum disorder
intellectual disability
high fat diet
functional connectivity
pregnant women
estrogen receptor
healthcare
endoplasmic reticulum
breast cancer cells
prefrontal cortex
adipose tissue
type diabetes
insulin resistance
temporal lobe epilepsy