Broadening our understanding of the genetics of Juvenile Idiopathic Arthritis (JIA): Interrogation of three dimensional chromatin structures and genetic regulatory elements within JIA-associated risk loci.

Kaiyu JiangHaeja KesslerYungki ParkMarc SudmanSusan D ThompsonJames N Jarvis

Published in: PloS one (2020)

These studies provide evidence that altered enhancer function contributes to genetic risk in JIA. Further studies to identify the specific target genes of genetically altered enhancers are warranted.

Keyphrases

juvenile idiopathic arthritis
genome wide
transcription factor
disease activity
dna methylation
copy number
gene expression
high resolution
binding protein
mass spectrometry
bioinformatics analysis
genome wide association study
genome wide association