Exploring Disparities in Pancreatic Adenocarcinoma Outcomes Among Asian and Pacific Islander Subgroups.

Pancreatic adenocarcinoma (PDAC) is a challenging malignancy with known disparities in outcomes across ethnicities. Studies specifically investigating PDAC in Asian populations are sparse, overlooking the rich diversity within this group. This research seeks to fill that gap by examining survival differences across the broad spectrum of Asian ethnicities, acknowledging the complexity and varied experiences within these communities. Utilizing the National Cancer Database from 2004 to 2019, we categorized patients into East Asian, Southeast Asian, South Asian, and Pacific Islander groups. Non-Asian or Pacific Islanders were excluded. Overall Survival was analyzed using a Cox hazards model. The study consisted of 13,254 patients. Most patients were East Asian (59.4%, n=7,866). Southeast Asians exhibited the poorest survival in unadjusted analysis (HR: 1.32, 95%CI: 1.23-1.42, p<0.001) compared to South Asians who had the best. Multivariable analysis revealed significantly worse survival for East Asians and Pacific Islanders relative to South Asians, while Southeast Asians' results were not significantly different. Asian subgroup differences notably affect PDAC outcomes. Research on genetic and cultural aspects, especially in Southeast Asians, and tackling health disparities, is crucial for enhancing survival in this diverse disease.