Discovery of Molecular DNA Methylation-Based Biomarkers through Genome-Wide Analysis of Response Patterns to BCG for Bladder Cancer.
Dafina IlijaziWalter PulvererIris E ErtlUrsula LembergerShoji KimuraMohammad AbufarajDavid d'AndreaBenjamin PradereAndreas BruchbacherAnna GrafFrancesco SoriaMartin SusaniAndrea HaitelLuca MolinaroArmin PychaEvi ComplojStephan PabingerAndreas WeinhäuselGerda EggerShahrokh F ShariatMelanie R HasslerPublished in: Cells (2020)
Tumors from BCG responders and BCG failures harbor distinct DNA methylation profiles. Differentially methylated DNA regions were detected in genes related to pathways involved in bacterial invasion of cells or focal adhesion. We identified candidate DNA methylation biomarkers that may help to predict patient prognosis after external validation in larger, well-designed cohorts.
Keyphrases
- dna methylation
- genome wide
- genome wide analysis
- gene expression
- induced apoptosis
- single molecule
- small molecule
- copy number
- cell cycle arrest
- circulating tumor
- case report
- high throughput
- oxidative stress
- escherichia coli
- signaling pathway
- nucleic acid
- cystic fibrosis
- pi k akt
- endoplasmic reticulum stress
- drug induced
- cell adhesion