Transcriptome profile of the sinoatrial ring reveals conserved and novel genetic programs of the zebrafish pacemaker.

Rashid MinhasHenry Loeffler-WirthYusra H SiddiquiTomasz ObrębskiShikha VashishtKarim Abu NahiaAlexandra PaterekAngelika BrzozowskaLukasz BugajskiKatarzyna PiwockaVladimir KorzhHans BinderCecilia Lanny Winata

Published in: BMC genomics (2021)

Our results established conserved aspects between zebrafish and mammalian pacemaker function and revealed novel factors implicated in maintaining cardiac rhythm. The transcriptome data generated in this study represents a unique and valuable resource for the study of pacemaker function and associated heart diseases.

Keyphrases

single cell
genome wide
gene expression
atrial fibrillation
rna seq
transcription factor
vena cava
public health
dna methylation
electronic health record
blood pressure
copy number
big data
pulmonary embolism
deep learning