The current study provides compelling evidence that RK effectively inhibits the TLR-4/NF-κB pathway via the gut-brain axis, leading to the improvement of LPS-induced depression-like behaviors in mice. This study addresses the research gap in understanding the antidepressant effects of RK and illuminates the potential of utilizing RK as a functional food for preventing depression.
Keyphrases
- lps induced
- inflammatory response
- signaling pathway
- toll like receptor
- depressive symptoms
- pi k akt
- immune response
- sleep quality
- white matter
- epithelial mesenchymal transition
- nuclear factor
- high fat diet induced
- oxidative stress
- resting state
- major depressive disorder
- type diabetes
- human health
- mouse model
- physical activity
- risk assessment
- functional connectivity
- adipose tissue
- subarachnoid hemorrhage
- multiple sclerosis
- endoplasmic reticulum stress
- insulin resistance