Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures.
Roman A LukaszewskiHelen E JonesVivian H GersukPaul RussellAndrew SimpsonDavid BrealeyJonathan WalkerMatt ThomasTony WhitehouseMarlies OstermannAlexander KochKai ZacharowskiMogens KruhofferDamien ChaussabelMervyn SingerPublished in: Intensive care medicine (2022)
Host biomarker signatures may be able to identify postoperative infection or sepsis up to three days in advance of clinical recognition. If validated in future studies, these signatures offer potential diagnostic utility for postoperative management of deteriorating or high-risk surgical patients and, potentially, other patient populations.