Pharmacogenomic Analysis of CYP3A5*3 and Tacrolimus Trough Concentrations in Vietnamese Renal Transplant Outcomes.
Thi Van Anh NguyenBa Hai LeMinh Thanh NguyenViet Thang LeViet Tien TranTuan Dinh LeDuong Anh Minh VuTruong Quy KienTrong Hieu LeThi Lien Huong NguyenPublished in: Pharmacogenomics and personalized medicine (2024)
The incorporation of the CYP3A5 phenotype into Zhu's structural model has significantly enhanced our ability to predict Tacrolimus trough levels in the Vietnamese population. This study's results underscore the valuable role of CYP3A5 phenotype in optimizing the forecast of Tac concentrations, offering a promising avenue to assist health-care practitioners in their clinical decision-making and ultimately advance patient care outcomes.