Lack of association between valproic acid response and polymorphisms of its metabolism, transport, and receptor genes in children with focal seizures.

Weixing FengShenghui MeiJiaqi HanLeting ZhuYazhen YuBaoqin GaoYun WuJiuwei LiZhigang ZhaoFang Fang

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2018)

Selected genetic polymorphisms were not significantly associated with VPA response in children with focal seizures. However, three GABR variants showed potential to be associated with the response to VPA. Further and larger studies are warranted to confirm the results.

Keyphrases

young adults
copy number
genome wide
risk assessment
case control
human health
climate change
genome wide identification