Extracellular vesicles from equine mesenchymal stem cells decrease inflammation markers in chondrocytes in vitro.

Magdalena Arévalo-TurrubiarteMario BarattaGiovanna PontiElisabetta ChiaradiaEugenio Martignani

Published in: Equine veterinary journal (2021)

EVs isolated from equine bone marrow MSCs reduced metalloproteinase 13 gene expression; this gene encodes an enzyme related to cartilage degradation in inflamed chondrocytes in vitro. EVs derived from MSCs can reduce inflammation and could potentially be used as an adjuvant treatment to improve tissue and cartilage repair in the articular pathologies.

Keyphrases

mesenchymal stem cells
bone marrow
umbilical cord
extracellular matrix
gene expression
oxidative stress
early stage
dna methylation
cell therapy
genome wide
copy number
stem cells
smoking cessation
drug induced