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Inhibition of Ribonucleotide Reductase Induces Endoplasmic Reticulum Stress and Apoptosis, Leading to the Death of Docetaxel-resistant Prostate Cancer Cells.

Riza SerttasSuat Erdogan
Published in: Anti-cancer agents in medicinal chemistry (2023)
Based on our findings, triapine emerges as a promising chemotherapeutic approach for combating docetaxel-resistant prostate cancer.
Keyphrases
  • endoplasmic reticulum stress
  • prostate cancer
  • induced apoptosis
  • locally advanced
  • radical prostatectomy
  • oxidative stress
  • squamous cell carcinoma
  • radiation therapy
  • cell death
  • cell cycle arrest